Nuclear respiratory factor-1 and bioenergetics in tamoxifen-resistant breast cancer cells

Antiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

Antiproliferative effects of flavonoid fractions from Calendula officinalis flowers in parent and tamoxifen resistant T47D human breast cancer cells

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

Effects of Flavonoid Fractions from Calendula officinalis Flowers in Parent and Tamoxifen Resistant T47D Human Breast Cancer Cells

      Three major flavonoid fractions were separated from a methanol extract of Calendula officinalis flowers by preparative TLC. These fractions were evaluated for the inhibition of parent and tamoxifen resistant T47D human breast cancer cells. We also examined the effect of ...

Tamoxifen Resistant Breast Cancer and Autophagy

cytotoxic activities of silver nanoparticles and silver ions in parent and tamoxifen-resistant t47d human breast cancer cells and their combination effects with tamoxifen against resistant cells

studies on biomedical applications of nanoparticles are growing with a rapid pace. in medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major drawback in chemotherapy of cancer. in the present study, we investigated the potential cytotoxic effect of silver nanoparticles (ag nps) and silver ions (ag+) in both parent and tamoxifen-resistant t47d cells in prese...